Clomid (Clomifen)

Drug Info

• Brand Name: Clomid;
• Active Ingredient: Clomifen Citrate;
• Manufacturer: Sanofi, Pacific, Bruno Pharma.

Active substance Clomifen

Clomifen (Clomiphene) was approved for medical use in 1967. This is a drug from the category of ovulation inducers, which is listed by the WHO.

Clomifen has a pronounced antiestrogenic effect.

Estrogens play an important role in the process of conception. This hormone:

• Stimulates the secretion of cervical mucus (a favorable environment necessary for the life, movement and nutrition of spermatozoa);
• Stimulates the release of luteinizing hormone (LH);
• Promotes the regeneration and growth of the endometrium.

Deficiency or excess of estrogen can lead to the impossibility of ovulation, and therefore pregnancy.

Clomifen provides a unique therapeutic effect. It does not directly affect the concentration of estrogen in the blood, but affects the estrogen receptors, which themselves regulate the level of the hormone.

In estrogen deficiency, these receptors increase their activity, while with an excess of estrogen - they decrease their activity.

Clomid only helps to create conditions for a natural change in the level of estrogen in the female body. Accordingly, it is not a drug of hormone replacement therapy and it does not have negative effects on the female body.

Under the influence of the drug, the concentration of luteinizing and follicle-stimulating hormones temporarily increases in the female body.

This effect usually lasts for 5 days, after which the concentration of these hormones drops. But, with a probability of more than 76 %, one or more follicles appear and mature, which leads to an increase in estrogen concentration, thus ultimately causing a mid-cycle LH surge and ovulation.

Indications for use

Clomid is prescribed for pathologies caused by an imbalance of female sex hormones in the body, such as:

• Absence of menstruation — amenorrhea;
• Too rare periods — oligomenorrhea;
• Dysfunctional uterine bleeding;
• Milky nipple discharge unrelated to breast-feeding — galactorrhea;
• Low sperm count in males — oligospermia;
• Male breast enlargement — gynecomastia.

As seen from the indications, Clomid is also recommended for males with an increase in estrogen levels. In the male body, it acts identically and helps to reduce the level of female sex hormones and increase testosterone.

Ways of buying Clomid

Clomid is a prescription drug sold in most city pharmacies. You can go to your doctor, pass an examination, get a prescription and buy pills at a drug store near you.

But this is not always the best method. You will have to pay for the doctor’s consultation, and Clomid tablets will be quite expensive in a local pharmacy. They may be at least 3 times more expensive than at an online pharmacy.

In our online pharmacy you can also buy Clomid, but at a much lower price. Minimizing the cost of maintaining an Internet resource and direct supplies from the manufacturer make the price of Clomid online the most suitable for most people with low and middle income. We make sure that each customer of our pharmacy has access to cheap medicines and can take care of their health without restrictions.

Compare the prices yourself and you will see that buying Clomid online in our pharmacy is more profitable and will not affect your budget.

Treatment regimens and dosages

For the successful treatment of anovulatory infertility, Clomid is used in cycles/stages of 5 days for 1–6 months (depending on the rate of ovulation onset).

The first stage of treatment begins on the 5th day of the menstrual cycle. Take 1 tablet of Clomid 50 mg per day for 5 days. After the end of taking the pills, you need to control the appearance of ovulation. It may begin 7–18 days after the end of treatment. If this does not happen, it is necessary to repeat the treatment course.

For the second and subsequent stages of treatment, you need to increase the dose of Clomid to 100 mg per day. The regimen repeats: start the treatment on the 5th day of the menstrual cycle and continue for 10 days. An increase in the duration of treatment is necessary for longer control of estrogen receptors.

Clomid 100 mg tablets are taken for at least 2–4 cycles to evaluate the effectiveness of the drug and identify comorbidities that affect the possibility of conception.

Males with oligospermia are advised to begin treatment with a minimum daily dose of Clomid 25 mg.

Tablets are taken 2–3 times a day for 3–4 months. If the spermogram parameters do not show positive dynamics after a month of treatment, the dosage can be increased to 50 mg, 2–3 times a day. The total daily dose should not exceed 150 mg.

Recommendations for use

Please note that treatment begins with a minimum dose to test Clomifen tolerance.

• Tablets are taken daily, regardless of food intake, without missing a single dose.
• It is very important to begin taking the pills from the 5th day of the menstrual cycle — no later and no earlier.
• If menstruation is absent, start the treatment on any day.

To determine the effectiveness of Clomid, after each cycle of treatment, it is necessary to conduct a transvaginal ultrasound examination to check the development of follicles.

If ovulation does not occur, the treatment is repeated.

Missed Dose

You should not miss a single dose of Clomid. If you miss a dose, you will need to start the entire course of treatment from scratch. Taking a double or triple dose will not make a difference and may cause side effects. So, it is necessary to carefully follow the dosing regimen.

Precautions

The use of Clomid is strictly contraindicated with the following diagnoses:

• Severe liver/renal failure;
• Uterine bleeding of unknown origin;
• Neoplasms in the pituitary gland;
• Pathological dysfunctions of the pituitary gland;
• Endometriosis.

Use of Clomid during pregnancy

Clomid is used to improve the reproductive function of males and females. But you should not use it during pregnancy. The use of the drug during pregnancy can cause miscarriage and terminate the pregnancy.

You should also avoid using the drug during breastfeeding.

Possible side effects

The most common side effect of Clomid is reversible ovarian enlargement in females. This effect is natural with an increase in the level of female sex hormones, so it will not cause much discomfort.

More rare symptoms are as follows: headaches, hot flashes, abdominal discomfort/pain.

Very rarely (in less than 1 % of patients), taking Clomid can cause inflammation of the liver, changes in blood count, uterine bleeding.

Doctors also include the possibility of multiple ovulations and the likelihood of conceiving twins or triplets as side effects. However, this is not often the case.

Clomid: interaction with other drugs

Due to the specific mechanism of pharmacological action, Clomifen does not interact with most known drugs. For this reason, treatment is carried out without specific restrictions.

You just need to remember that during treatment:

• You should give up alcohol;
• You should not take two drugs with a similar effect at once, for example, Clomid and Tamoxifen;
• You can use additional drugs of gonadotropic hormones.

Storage

Store in a dark place, out of the reach of children, at a temperature not exceeding 25°C.

How to buy Clomid online?

The pricing policy of our online pharmacy is designed for the widest range of consumers. Even if you have a small income, this does not mean that you should deny yourself.

Maintaining reproductive health is our goal. Therefore, our employees do everything so that every woman and man has the opportunity to buy Clomid at low prices and does not abandon the hope of conceiving a child.

We offer our customers:

• Prices below market;
• 24/7 technical support;
• Fast delivery to your home;
• Complete safety and anonymity of each order.

Buying Clomid online, you get the opportunity to fulfill your dream and have a baby.